Unveiling the zoonotic dynamics of Leprosy in Brazil: a molecular exploration and surveillance approach

Entry requirements

Please use this Research Proposal, Personal statement and CV: GUIDE when preparing an application.

Months of entry

Anytime

Course content

The WHO's Global Leprosy Strategy 2021–2030 identifies zoonotic reservoirs as a critical obstacle to leprosy eradication, particularly emphasizing the need for country-specific strategies in endemic regions. Brazil is a focal point for leprosy, accounting for 94% of Latin American cases, with approximately 28,000 new cases reported annually. Understanding the role of zoonotic transmission, especially from armadillos, is crucial for developing effective eradication strategies. Human-to-human transmission is the primary route for leprosy; however, recent studies have highlighted the significant role of armadillos as zoonotic reservoirs, particularly among hunters and consumers. Despite evidence of Mycobacterium leprae and M. lepromatosis infections in armadillos, zoonotic aspects of leprosy remain underexplored in Brazil, limiting public health measures to address the disease comprehensively.

This PhD project aims to:

1. Investigate the contribution of armadillos to leprosy transmission in Brazil using PCR-based assays and whole genome sequencing (WGS).
2. Explore the prevalence and genetic diversity of M. leprae and M. lepromatosis in armadillos and humans.
3. Apply advanced sequencing technologies to enhance the detection, characterization, and genomic profiling of leprosy-causing bacteria.

Impact:
This project aligns with WHO's goal to develop integrated zero-leprosy road maps in endemic countries. The findings will enhance understanding of zoonotic transmission pathways, inform public health strategies, and contribute to global efforts in scaling up leprosy prevention.

Eligibility & Skills Required:
We seek a motivated candidate with an interest in wildlife, disease ecology, microbiology, genomics, or a related field. Experience with molecular biology techniques or bioinformatics is desirable but not essential.

Fees and funding

This programme is self-funded.

To enquire about University of Salford funding schemes – including the Widening Participation Scholarship – visit this website.